Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells
Joint Authors
Qi, Xue
Xu, Yuzhen
Liu, Xueyuan
Yu, Tongya
Lin, Yingying
Dou, Yunxiao
Wang, Feihong
Zhao, Yanxin
Quan, Hui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Compelling evidence from basic molecular biology has demonstrated the crucial role of microglia in the pathogenesis of Alzheimer’s disease (AD).
Microglia were believed to play a dual role in both promoting and inhibiting Alzheimer’s disease progression.
It is of great significance to regulate the function of microglia and make them develop in a favorable way.
In the present study, we investigated the function of repressor element 1-silencing transcription factor (REST) in Aβ1-42-induced BV-2 cell dysfunction.
We concluded that Aβ1-42 could promote type I activation of BV-2 cells and induce cell proliferation, migration, and proinflammation cytokine TNF-α, IL-1β, and IL-6 expression.
Meanwhile, REST was upregulated, and nuclear translocalization took place due to Aβ1-42 stimulation.
When REST was knocked down by a specific short hairpin RNA (sh-RNA), BV-2 cell proliferation, migration, and proinflammation cytokine expression and secretion induced by Aβ1-42 were increased, demonstrating that REST may act as a repressor of microglia-like BV-2 cell activation.
American Psychological Association (APA)
Yu, Tongya& Quan, Hui& Xu, Yuzhen& Dou, Yunxiao& Wang, Feihong& Lin, Yingying…[et al.]. 2020. Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells. Neural Plasticity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203120
Modern Language Association (MLA)
Yu, Tongya…[et al.]. Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells. Neural Plasticity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1203120
American Medical Association (AMA)
Yu, Tongya& Quan, Hui& Xu, Yuzhen& Dou, Yunxiao& Wang, Feihong& Lin, Yingying…[et al.]. Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203120