Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity

Joint Authors

Wojciechowski, David
Gupta, Shruti
Rosales, Ivy

Source

Journal of Transplantation

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-02

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Background.

Calcineurin inhibitors are associated with chronic nephrotoxicity, manifesting as interstitial fibrosis/tubular atrophy (IF/TA) and arteriolar hyalinosis.

Conversion from tacrolimus to belatacept may be one strategy to preserve renal function.

Methods.

We conducted a retrospective review of renal transplant patients followed at our institution who were converted to belatacept and found to have chronic tacrolimus toxicity on biopsy.

The primary outcome was eGFR at conversion as compared to eGFR at 3, 6, 12, and 24 months after conversion.

We also assessed incidence of infection and rates of allograft survival at 1 year.

Results.

The average time between transplant and conversion was 11.9 years.

There was no decrease in eGFR at any postconversion time point as compared with preconversion.

The mean eGFR at time of preconversion was 32.9 mL/min, as compared with 35.6 mL/min at 3 months (p=0.09), 34.1 mL/min at 6 months (p=0.63), 34.9 mL/min at 12 months (p=0.57), and 39.6 mL/min at 24 months after conversion (p=0.92).

Four of 7 patients had increases in their eGFR after conversion.

All grafts were functioning at 1 year after conversion.

Conclusion.

While this study was limited by a small number of patients, belatacept conversion stabilized eGFR at all time points in patients with late allograft function due to chronic tacrolimus toxicity, with a trend towards increased eGFR at 3 months.

American Psychological Association (APA)

Gupta, Shruti& Rosales, Ivy& Wojciechowski, David. 2018. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203126

Modern Language Association (MLA)

Gupta, Shruti…[et al.]. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203126

American Medical Association (AMA)

Gupta, Shruti& Rosales, Ivy& Wojciechowski, David. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203126

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1203126