Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity
Joint Authors
Wojciechowski, David
Gupta, Shruti
Rosales, Ivy
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Calcineurin inhibitors are associated with chronic nephrotoxicity, manifesting as interstitial fibrosis/tubular atrophy (IF/TA) and arteriolar hyalinosis.
Conversion from tacrolimus to belatacept may be one strategy to preserve renal function.
Methods.
We conducted a retrospective review of renal transplant patients followed at our institution who were converted to belatacept and found to have chronic tacrolimus toxicity on biopsy.
The primary outcome was eGFR at conversion as compared to eGFR at 3, 6, 12, and 24 months after conversion.
We also assessed incidence of infection and rates of allograft survival at 1 year.
Results.
The average time between transplant and conversion was 11.9 years.
There was no decrease in eGFR at any postconversion time point as compared with preconversion.
The mean eGFR at time of preconversion was 32.9 mL/min, as compared with 35.6 mL/min at 3 months (p=0.09), 34.1 mL/min at 6 months (p=0.63), 34.9 mL/min at 12 months (p=0.57), and 39.6 mL/min at 24 months after conversion (p=0.92).
Four of 7 patients had increases in their eGFR after conversion.
All grafts were functioning at 1 year after conversion.
Conclusion.
While this study was limited by a small number of patients, belatacept conversion stabilized eGFR at all time points in patients with late allograft function due to chronic tacrolimus toxicity, with a trend towards increased eGFR at 3 months.
American Psychological Association (APA)
Gupta, Shruti& Rosales, Ivy& Wojciechowski, David. 2018. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203126
Modern Language Association (MLA)
Gupta, Shruti…[et al.]. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203126
American Medical Association (AMA)
Gupta, Shruti& Rosales, Ivy& Wojciechowski, David. Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203126