Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
Joint Authors
Fan, Wen
Guo, Yongming
Gong, Yinan
Wang, Jiaqi
Xu, Zhifang
Guo, Yi
Tang, Huiling
Zhao, Yadan
Wang, Songtao
Qin, Siru
Chen, Zelin
Fang, Yuxin
Li, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Spinal cord injury (SCI) is a structural event with devastating consequences worldwide.
Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult.
Acupuncture is effective for SCI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve neural protection by the inhibition of inflammation, oxidation, and apoptosis.
Moreover, acupuncture promotes neural regeneration and axon sprouting by activating multiple cellular signal transduction pathways, such as the Wnt, Notch, and Rho/Rho kinase (ROCK) pathways.
Several studies have demonstrated that the efficacy of combining acupuncture with mesenchymal stem cells (MSCs) transplantation is superior to either procedure alone.
The advantage of the combined treatment is dependent on the ability of acupuncture to enhance the survival of MSCs, promote their differentiation into neurons, and facilitate targeted migration of MSCs to the spinal cord.
Additionally, the differentiation of MSCs into neurons overcomes the problem of the shortage of endogenous neural stem cells (NSCs) in the acupuncture-treated SCI patients.
Therefore, the combination of acupuncture and MSCs transplantation could become a novel and effective strategy for the treatment of SCI.
Such a possibility needs to be verified by basic and clinical research.
American Psychological Association (APA)
Tang, Huiling& Guo, Yi& Zhao, Yadan& Wang, Songtao& Wang, Jiaqi& Li, Wei…[et al.]. 2020. Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203130
Modern Language Association (MLA)
Tang, Huiling…[et al.]. Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203130
American Medical Association (AMA)
Tang, Huiling& Guo, Yi& Zhao, Yadan& Wang, Songtao& Wang, Jiaqi& Li, Wei…[et al.]. Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203130