Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
Joint Authors
Picada, Jaqueline N.
Rodrigues, Graziella
Moreira, Andrea Janz
Schemitt, Elizângela
Marroni, Cláudio Augusto
Dias, Alexandre Simões
Pires, Thienne Rocha
Marroni, Norma Possa
Bona, Sílvia
Di Naso, Fábio Cangeri
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
In this study, we evaluated the efficacy of simvastatin in the treatment of nonalcoholic steatohepatitis induced by methionine and choline-deficient diet in mice and its possible effect on factors involved in the pathogenesis of the disease including oxidative stress and endoplasmic reticulum stress.
Method.
Male C57BL6 mice were fed either a normal diet (control) or a methionine and choline-deficient diet for four weeks and then treated orally with simvastatin (4 mg/kg once a day) for two final weeks.
At the end of the experimental period, liver integrity, biochemical analysis, hepatic lipids, histology, DNA damage, biomarkers of oxidative stress, and endoplasmic reticulum stress were assessed.
Results.
Simvastatin treatment was able to significantly reduce hepatic damage enzymes and hepatic lipids and lower the degree of hepatocellular ballooning, without showing genotoxic effects.
Simvastatin caused significant decreases in lipid peroxidation, with some changes in antioxidant enzymes superoxide dismutase and glutathione peroxidase.
Simvastatin activates antioxidant enzymes via Nrf2 and inhibits endoplasmic reticulum stress in the liver.
Conclusions.
In summary, the results provide evidence that in mice with experimental nonalcoholic steatohepatitis induced by a methionine and choline-deficient diet, the reduction of liver damage by simvastatin is associated with attenuated oxidative and endoplasmic reticulum stress.
American Psychological Association (APA)
Rodrigues, Graziella& Moreira, Andrea Janz& Bona, Sílvia& Schemitt, Elizângela& Marroni, Cláudio Augusto& Di Naso, Fábio Cangeri…[et al.]. 2019. Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1203143
Modern Language Association (MLA)
Rodrigues, Graziella…[et al.]. Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1203143
American Medical Association (AMA)
Rodrigues, Graziella& Moreira, Andrea Janz& Bona, Sílvia& Schemitt, Elizângela& Marroni, Cláudio Augusto& Di Naso, Fábio Cangeri…[et al.]. Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1203143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203143