![](/images/graphics-bg.png)
Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?
Joint Authors
Assadiasl, Sara
Mousavi, Mohammad Javad
Amirzargar, Aliakbar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology.
On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability.
Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal.
However, survivin’s potential ability to induce malignancies makes some concerns about its use in clinic.
The other barrier is this molecule’s involvement in lymphocytes development and proliferation which might increase the risk of graft rejection due to adaptive immune system overactivation.
In this review we summarize the few studies carried out about survivin’s effect on graft survival and probable advantages and disadvantages of its overexpression in transplantation.
American Psychological Association (APA)
Assadiasl, Sara& Mousavi, Mohammad Javad& Amirzargar, Aliakbar. 2018. Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203146
Modern Language Association (MLA)
Assadiasl, Sara…[et al.]. Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?. Journal of Transplantation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203146
American Medical Association (AMA)
Assadiasl, Sara& Mousavi, Mohammad Javad& Amirzargar, Aliakbar. Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203146