New Insights into the Nrf-2HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
Joint Authors
Zhu, Ping
Huang, Huanlei
Zhao, Mingyi
Zhang, Xueyan
Cai, Yufeng
Shen, Jie
He, Qingnan
Ding, Ming
Zhuang, Quan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Respiratory diseases are one of the most common pediatric diseases in clinical practice.
Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation.
The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection chain that protects against oxidative stress injury.
This signaling axis regulates anti-inflammation and antioxidation by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis, apoptosis, alkaliptosis, and clockophagy.
This review presents an overview of the role of the Nrf2/HO-1 signaling axis in the pathogenesis of pediatric respiratory diseases and the latest research progress on this subject.
Overall, the Nrf2/HO-1 signaling axis has an important clinical value in pediatric respiratory diseases, and its protective effect needs further exploration.
American Psychological Association (APA)
Zhang, Xueyan& Ding, Ming& Zhu, Ping& Huang, Huanlei& Zhuang, Quan& Shen, Jie…[et al.]. 2019. New Insights into the Nrf-2HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203158
Modern Language Association (MLA)
Zhang, Xueyan…[et al.]. New Insights into the Nrf-2HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203158
American Medical Association (AMA)
Zhang, Xueyan& Ding, Ming& Zhu, Ping& Huang, Huanlei& Zhuang, Quan& Shen, Jie…[et al.]. New Insights into the Nrf-2HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203158