Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population
Joint Authors
Li, Yuxia
Kang, Meimei
Sheng, Can
Chen, Guanqun
Li, Taoran
Wang, Jun
Cai, Yanning
Wang, Rong
Han, Ying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population.
We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing.
There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups.
Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (0.6541) ng/mL] than in subjects without ApoE ɛ4 [0.4368 (0.3392) ng/mL and 0.5287 (0.3656) ng/mL], and urinary AD7c-NTP levels positively correlated with ApoE genotype grade (r=0.165, p=0.003).
There were significant differences in urinary AD7c-NTP levels between subjects with and without a history of coronary heart disease or diabetes.
Urinary AD7c-NTP levels were not related to years of education, nature of work, family history of dementia, a history of hypertension, stroke, anemia, or thyroid dysfunction.
Urinary AD7c-NTP levels were positively correlated with ApoE grade in the cognitively normal population.
The relationship between risk factors of cognitive decline and urinary AD7c-NTP levels provides a new way for us to understand AD and urinary AD7c-NTP.
American Psychological Association (APA)
Li, Yuxia& Kang, Meimei& Sheng, Can& Chen, Guanqun& Li, Taoran& Wang, Jun…[et al.]. 2020. Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population. Neural Plasticity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203197
Modern Language Association (MLA)
Li, Yuxia…[et al.]. Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population. Neural Plasticity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203197
American Medical Association (AMA)
Li, Yuxia& Kang, Meimei& Sheng, Can& Chen, Guanqun& Li, Taoran& Wang, Jun…[et al.]. Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203197