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Suppression of Gut Bacterial Translocation Ameliorates Vascular Calcification through Inhibiting Toll-Like Receptor 9-Mediated BMP-2 Expression
Joint Authors
Wang, Xian
Cai, Yan
Zhao, Yang
Cui, Li-Yan
Tang, Wen
Liu, Bo
Zheng, Jia-Jia
Si, Wen-Zhe
Xu, Ming-Jiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aims.
Vascular calcification (VC) is a primary risk factor for cardiovascular mortality in chronic renal failure (CRF) patients; thus, effective therapeutic targets are urgently needed to be explored.
Here, we identified the role of intestinal bacterial translocation in CRF-related VC.
Methods and Results.
Antibiotic supplementation by oral gavage significantly suppressed intestinal bacterial translocation, CRF-related VC, and aortic osteogenic gene and Toll-like receptor (TLR) gene expression in CRF rats.
Furthermore, TLR4 and TLR9 activation in vascular smooth muscle cells (VSMCs) aggravated inorganic phosphate- (Pi-) induced calcification.
TLR9 inhibition, but not TLR4 inhibition, by both a pharmacological inhibitor and genetic methods could significantly reduce CRF rats’ serum or CRF-induced VC.
Interestingly, bone morphogenic protein-2 (BMP-2) levels were increased in the aorta and sera from CRF rats.
Increased BMP-2 levels were also observed in VSMCs treated with TLR9 agonist, which was blocked by NF-κB inhibition.
Both siRNA knockdown of BMP-2 and NF-κB inhibitor significantly blocked TLR9 agonist-induced VSMC calcification.
Conclusions.
Gut bacterial translocation inhibited by oral antibiotic significantly reduces CRF-related VC through inhibition of TLR9/NF-κB/BMP-2 signaling.
American Psychological Association (APA)
Zhao, Yang& Cai, Yan& Cui, Li-Yan& Tang, Wen& Liu, Bo& Zheng, Jia-Jia…[et al.]. 2019. Suppression of Gut Bacterial Translocation Ameliorates Vascular Calcification through Inhibiting Toll-Like Receptor 9-Mediated BMP-2 Expression. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203208
Modern Language Association (MLA)
Zhao, Yang…[et al.]. Suppression of Gut Bacterial Translocation Ameliorates Vascular Calcification through Inhibiting Toll-Like Receptor 9-Mediated BMP-2 Expression. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1203208
American Medical Association (AMA)
Zhao, Yang& Cai, Yan& Cui, Li-Yan& Tang, Wen& Liu, Bo& Zheng, Jia-Jia…[et al.]. Suppression of Gut Bacterial Translocation Ameliorates Vascular Calcification through Inhibiting Toll-Like Receptor 9-Mediated BMP-2 Expression. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203208