Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia
Joint Authors
Yimam, Mohammed
Tefera, Gosaye Mekonen
Zewudie, Ameha
Mamo, Yitagesu
Feyissa, Desalegn
Abdela, Ahmed
Source
Neurology Research International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price.
In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures.
Thus, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia.
Methods.
A hospital-based cross-sectional study involving patient interview and chart review was conducted from March 10 to April 10, 2018.
Drug use patterns and sociodemographic data of the study participants were accustomed to descriptive statistics.
Backward logistic regression analysis was done to identify predictors of poor seizure control.
Statistical significance was considered at p value <0.05.
Results.
From a total of 143 studied patients with epilepsy, 60.8% had uncontrolled seizures.
Monotherapy (79%) was commonly used for the treatment of seizures, of which phenobarbital was the most commonly utilized single anticonvulsant drug (62.9%).
The majority (72.7%) of the patients had developed one or more antiepileptic-related adverse effects.
Medium medication adherence (adjusted odds ratio (AOR) = 5.4; 95% CI = 1.52–19.23; p=0.009), poor medication adherence (AOR = 8.16; 95% CI = 3.04–21.90; p=0.001), head injury before seizure occurrence (AOR = 4.9; 95% CI = 1.25–19.27; p=0.02), and seizure attacks ≥4 episodes/week before AEDs initiation (AOR = 8.52; % CI = 2.41–13.45; p=0.001) were the predictors of uncontrolled seizure.
Conclusions.
Based on our findings, more than half of the patients with epilepsy had poorly controlled seizures.
Nonadherence to antiepileptic drugs, high frequency of seizure attack before AEDs initiation, and history of a head injury before the occurrence of seizure were predictors of uncontrolled seizure.
Patient medication adherence should be increased by the free access of antiepileptic drugs and attention should be given for the patients with a history of head injury and high frequency of seizure attacks before AEDs initiation.
American Psychological Association (APA)
Zewudie, Ameha& Mamo, Yitagesu& Feyissa, Desalegn& Yimam, Mohammed& Tefera, Gosaye Mekonen& Abdela, Ahmed. 2020. Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Neurology Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203240
Modern Language Association (MLA)
Zewudie, Ameha…[et al.]. Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Neurology Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1203240
American Medical Association (AMA)
Zewudie, Ameha& Mamo, Yitagesu& Feyissa, Desalegn& Yimam, Mohammed& Tefera, Gosaye Mekonen& Abdela, Ahmed. Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Neurology Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203240