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Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis
Joint Authors
de Abreu, Luiz C.
do Carmo Almeida, Tábata Cristina
dos Santos Figueiredo, Francisco Winter
Barbosa Filho, Valter Cordeiro
Adami, Fernando
Fonseca, Fernando L. A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood.
Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in six databases to identify randomized controlled trials with the criteria: humans older than 18 years (adults), use of TENS in the experimental group, and having at least one pre- and postintervention blood level of at least one proinflammatory cytokine.
The risk of bias and the level of evidence were assessed.
Five studies were included involving 240 participants.
The heterogeneity of the studies was high (I2: 85%); therefore, we used a random-effects meta-analysis.
It was observed through the meta-analysis synthesis measures that there were statistically significant differences following the use of TENS to reduce the general group of cytokines.
When grouped by chronic disease, by postoperative settings, or by individual studies in the case of IL-6, it was observed that the significant reduction of cytokines related to the use of TENS was maintained.
The use of TENS reduced the blood levels of proinflammatory cytokines (we observed a protective factor of TENS in relation to inflammation).
The protocol of the systematic review was registered in PROSPERO, CRD42017060379.
American Psychological Association (APA)
do Carmo Almeida, Tábata Cristina& dos Santos Figueiredo, Francisco Winter& Barbosa Filho, Valter Cordeiro& de Abreu, Luiz C.& Fonseca, Fernando L. A.& Adami, Fernando. 2018. Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203268
Modern Language Association (MLA)
do Carmo Almeida, Tábata Cristina…[et al.]. Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1203268
American Medical Association (AMA)
do Carmo Almeida, Tábata Cristina& dos Santos Figueiredo, Francisco Winter& Barbosa Filho, Valter Cordeiro& de Abreu, Luiz C.& Fonseca, Fernando L. A.& Adami, Fernando. Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203268