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Airway Epithelium Dysfunction in Cystic Fibrosis and COPD
Joint Authors
Pilette, Charles
De Rose, Virginia
Gohy, Sophie
Greene, Catherine M.
Molloy, Kevin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly cigarette smoking) on a genetically susceptible background.
Although the etiology and pathogenesis of these diseases are different, both are associated with progressive airflow obstruction, airway neutrophilic inflammation, and recurrent exacerbations, suggesting common mechanisms.
The airway epithelium plays a crucial role in maintaining normal airway functions.
Major molecular and morphologic changes occur in the airway epithelium in both CF and COPD, and growing evidence suggests that airway epithelial dysfunction is involved in disease initiation and progression in both diseases.
Structural and functional abnormalities in both airway and alveolar epithelium have a relevant impact on alteration of host defences, immune/inflammatory response, and the repair process leading to progressive lung damage and impaired lung function.
In this review, we address the evidence for a critical role of dysfunctional airway epithelial cells in chronic airway inflammation and remodelling in CF and COPD, highlighting the common mechanisms involved in the epithelial dysfunction as well as the similarities and differences of the two diseases.
American Psychological Association (APA)
De Rose, Virginia& Molloy, Kevin& Gohy, Sophie& Pilette, Charles& Greene, Catherine M.. 2018. Airway Epithelium Dysfunction in Cystic Fibrosis and COPD. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1203278
Modern Language Association (MLA)
De Rose, Virginia…[et al.]. Airway Epithelium Dysfunction in Cystic Fibrosis and COPD. Mediators of Inflammation No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1203278
American Medical Association (AMA)
De Rose, Virginia& Molloy, Kevin& Gohy, Sophie& Pilette, Charles& Greene, Catherine M.. Airway Epithelium Dysfunction in Cystic Fibrosis and COPD. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1203278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203278