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New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation
Joint Authors
Bisaccia, Faustino
Santarsiero, Anna
Leccese, Pietro
Convertini, Paolo
Padula, Angela
Abriola, Paolo
D’Angelo, Salvatore
Infantino, Vittoria
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To date, a major research effort on Behçet’s syndrome (BS) has been concentrated on immunological aspects.
Little is known about the metabolic reprogramming in BS.
Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier—SLC25A1-encoded protein—it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).
In induced macrophages, mitochondrial citrate is necessary for the production of inflammatory mediators.
The aim of our study was to evaluate SLC25A1 and ACLY expression levels in BS patients.
Following a power analysis undertaken on few random samples, the number of enrolled patients was set.
Thirty-nine consecutive BS patients fulfilling ISG criteria, and 21 healthy controls suitable for age and sex were recruited.
BS patients were divided into two groups according to the presence (active) or absence (inactive) of clinical manifestations.
Real-time PCR experiments were performed on PBMCs to quantify SLC25A1 and ACLY mRNA levels.
Data processing through the Kruskal-Wallis test and Dunn’s multiple comparison test as post hoc showed higher SLC25A1 and ACLY mRNA levels in BS patients compared to those in healthy controls.
Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation.
American Psychological Association (APA)
Santarsiero, Anna& Leccese, Pietro& Convertini, Paolo& Padula, Angela& Abriola, Paolo& D’Angelo, Salvatore…[et al.]. 2018. New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203295
Modern Language Association (MLA)
Santarsiero, Anna…[et al.]. New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203295
American Medical Association (AMA)
Santarsiero, Anna& Leccese, Pietro& Convertini, Paolo& Padula, Angela& Abriola, Paolo& D’Angelo, Salvatore…[et al.]. New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203295