Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice
Joint Authors
Burbano, Rommel Rodríguez
do Nascimento, José Luiz Martins
Hamoy, Moisés
de Góis Queiroz, Ana Isabelle
Maia, Cristiane Socorro Ferraz
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
Paraense, Ricardo Sousa de Oliveira
Macchi, Barbarella de Matos
Bittencourt, Leonardo Oliveira
Souza-Monteiro, José Rogério
Arrifano, Gabriela P. F.
Mello, Bruna S. F.
Custódio, Charllyany S.
Macêdo, Danielle S.
Rogez, Hervé
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half of those with the condition receive adequate treatment.
In addition, the high pharmacological refractoriness (affecting 30%-50% of patients) and toxicity of some classical antidepressants support the pursuit of new therapies.
People with this condition show depressed mood, loss of pleasure, high levels of oxidative stress, and accelerated biological aging (decreased telomere length and expression of the telomerase reverse transcriptase (TERT), the enzyme responsible for telomere maintenance).
Because of the close relationship between depression and oxidative stress, nutraceuticals with antioxidant properties are excellent candidates for therapy.
This study represents the first investigation of the possible antidepressant and antiaging effects of commercial samples of clarified açaí (Euterpe oleracea) juice (EO).
This fruit is rich in antioxidants and widely consumed.
In this study, mice were treated with saline or EO (10 μL/g, oral) for 4 days and then with saline or lipopolysaccharide (0.5 mg/kg, i.p.) to induce depressive-like behavior.
Only four doses of EO were enough to abolish the despair-like and anhedonia behaviors and alterations observed in electromyographic measurements.
The antidepression effect of EO was similar to that of imipramine and associated with antioxidant and antiaging effects (preventing lipid peroxidation and increasing TERT mRNA expression, respectively) in three major brain regions involved in depression (hippocampus, striatum, and prefrontal cortex).
Additionally, EO significantly protected hippocampal cells, preventing neuronal loss associated with the depressive-like state and nitrite level increases (an indirect marker of nitric oxide production).
Moreover, EO alone significantly increased TERT mRNA expression, revealing for the first time a potent antiaging action in the brain that suggests neuroprotection against long-term age-related consequences.
American Psychological Association (APA)
Souza-Monteiro, José Rogério& Arrifano, Gabriela P. F.& de Góis Queiroz, Ana Isabelle& Mello, Bruna S. F.& Custódio, Charllyany S.& Macêdo, Danielle S.…[et al.]. 2019. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
Modern Language Association (MLA)
Souza-Monteiro, José Rogério…[et al.]. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
American Medical Association (AMA)
Souza-Monteiro, José Rogério& Arrifano, Gabriela P. F.& de Góis Queiroz, Ana Isabelle& Mello, Bruna S. F.& Custódio, Charllyany S.& Macêdo, Danielle S.…[et al.]. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203296