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The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview
Joint Authors
Orozco-Suárez, Sandra
Guerra-Araiza, Christian
Gallardo, J. M.
Segura-Uribe, Julia J.
Coyoy-Salgado, Angélica
Salgado-Ceballos, Hermelinda
Feria-Romero, Iris A.
Orozco-Barrios, Carlos E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-12
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers.
Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI treatment.
Some compounds from traditional medicine could be useful to decrease ROS generated after SCI.
This review is aimed at highlighting the importance of some natural compounds with antioxidant capacity used in traditional medicine to treat traumatic SCI.
An electronic search of published articles describing animal models of SCI treated with natural compounds from traditional medicine was conducted using the following terms: Spinal Cord Injuries (MeSH terms) AND Models, Animal (MeSH terms) AND [Reactive Oxygen Species (MeSH terms) AND/OR Oxidative Stress (MeSH term)] AND Medicine, Traditional (MeSH terms).
Articles reported from 2010 to 2018 were included.
The results were further screened by title and abstract for studies performed in rats, mice, and nonhuman primates.
The effects of these natural compounds are discussed, including their antioxidant, anti-inflammatory, and antiapoptotic properties.
Moreover, the antioxidant properties of natural compounds were emphasized since oxidative stress has a fundamental role in the generation and progression of several pathologies of the nervous system.
The use of these compounds diminishes toxic effects due to their high antioxidant capacity.
These compounds have been tested in animal models with promising results; however, no clinical studies have been conducted in humans.
Further research of these natural compounds is crucial to a better understanding of their effects in patients with SCI.
American Psychological Association (APA)
Coyoy-Salgado, Angélica& Segura-Uribe, Julia J.& Guerra-Araiza, Christian& Orozco-Suárez, Sandra& Salgado-Ceballos, Hermelinda& Feria-Romero, Iris A.…[et al.]. 2019. The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1203312
Modern Language Association (MLA)
Coyoy-Salgado, Angélica…[et al.]. The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-22.
https://search.emarefa.net/detail/BIM-1203312
American Medical Association (AMA)
Coyoy-Salgado, Angélica& Segura-Uribe, Julia J.& Guerra-Araiza, Christian& Orozco-Suárez, Sandra& Salgado-Ceballos, Hermelinda& Feria-Romero, Iris A.…[et al.]. The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1203312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203312