Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis
Joint Authors
Zelante, Teresa
Giovagnoli, Stefano
Puccetti, Matteo
Paolicelli, Giuseppe
De Luca, Antonella
Renga, Giorgia
Borghi, Monica
Pariano, Marilena
Stincardini, Claudia
Scaringi, Lucia
Ricci, Maurizio
Romani, Luigina
Oikonomou, Vasileios
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome.
Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a cytosolic, ligand-operated transcription factor that is involved in many biological processes, including development, cellular differentiation and proliferation, xenobiotic metabolism, and the immune response.
Low-level activation of AhR by endogenous ligands is beneficial in the maintenance of immune health and intestinal homeostasis.
We have defined a functional node whereby certain bacteria species contribute to host/microbial symbiosis and mucosal homeostasis.
A microbial trp metabolic pathway leading to the production of indole-3-aldehyde (3-IAld) by lactobacilli provided epithelial protection while inducing antifungal resistance via the AhR/IL-22 axis.
In this review, we highlight the role of AhR in inflammatory lung diseases and discuss the possible therapeutic use of AhR ligands in cystic fibrosis.
American Psychological Association (APA)
Puccetti, Matteo& Paolicelli, Giuseppe& Oikonomou, Vasileios& De Luca, Antonella& Renga, Giorgia& Borghi, Monica…[et al.]. 2018. Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203317
Modern Language Association (MLA)
Puccetti, Matteo…[et al.]. Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203317
American Medical Association (AMA)
Puccetti, Matteo& Paolicelli, Giuseppe& Oikonomou, Vasileios& De Luca, Antonella& Renga, Giorgia& Borghi, Monica…[et al.]. Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203317