Predictive Value of Combined LIPS and ANG-2 Level in Critically Ill Patients with ARDS Risk Factors
Joint Authors
Li, Qi
Wang, Guansong
Xu, Zhi
Wu, Guo-Ming
Ji, Fu-Yun
Shi, Zhong
Guo, Hong
Yin, Jin-Bo
Zhou, Jian
Gong, Liang
Mei, Chun-Xia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To investigate the predictive value of the acute physiology and chronic health evaluation 2 (APACHE2) score and lung injury prediction score (LIPS) for acute respiratory distress syndrome (ARDS) when combined with biomarkers for this condition in patients with ARDS risk factors.
In total, 158 Han Chinese patients with ARDS risk factors were recruited from the Respiratory and Emergency Intensive Care Units.
The LIPS, APACHE2 score, primary diagnosis at admission, and ARDS risk factors were determined within 6 h of admission, and PaO2/FiO2 was determined on the day of admission.
Blood was collected within 24 h of admission for the measurement of angiopoietin-2 (ANG-2), sE-selectin, interleukin-6 (IL-6), and interleukin-8 (IL-8) levels.
ARDS was monitored for the next 7 days.
Univariate and multivariate analyses and receiver operating characteristic (ROC) analyses were employed to construct a model for ARDS prediction.
Forty-eight patients developed ARDS within 7 days of admission.
Plasma ANG-2 level, sE-selectin level, LIPS, and APACHE2 score in ARDS patients were significantly higher than those in non-ARDS patients.
ANG-2 level, LIPS, and APACHE2 score were correlated with ARDS (P<0.001, P<0.006, and P<0.042, resp.).
When the APACHE2 score was used in combination with the LIPS and ANG-2 level to predict ARDS, the area under the ROC curve (AUC) was not significantly increased.
Compared to LIPS or ANG-2 alone, LIPS in combination with ANG-2 had significantly increased positive predictive value (PPV) and AUC for the prediction of ARDS.
In conclusion, plasma ANG-2 level, LIPS, and APACHE2 score are correlated with ARDS.
Combined LIPS and ANG-2 level displays favorable sensitivity, specificity, and AUC for the prediction of ARDS.
American Psychological Association (APA)
Xu, Zhi& Wu, Guo-Ming& Li, Qi& Ji, Fu-Yun& Shi, Zhong& Guo, Hong…[et al.]. 2018. Predictive Value of Combined LIPS and ANG-2 Level in Critically Ill Patients with ARDS Risk Factors. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203344
Modern Language Association (MLA)
Xu, Zhi…[et al.]. Predictive Value of Combined LIPS and ANG-2 Level in Critically Ill Patients with ARDS Risk Factors. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203344
American Medical Association (AMA)
Xu, Zhi& Wu, Guo-Ming& Li, Qi& Ji, Fu-Yun& Shi, Zhong& Guo, Hong…[et al.]. Predictive Value of Combined LIPS and ANG-2 Level in Critically Ill Patients with ARDS Risk Factors. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203344