Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study
Joint Authors
Vargas-Alarcón, Gilberto
Rodríguez-Pérez, José Manuel
Pérez-Hernández, Nonanzit
Coral-Vázquez, Ramón
Posadas-Sánchez, Rosalinda
Villarreal-Molina, Teresa
Roque-Ramírez, Bladimir
Tejero-Barrera, Maria Elizabeth
Posadas-Romero, Carlos
Fragoso, José Manuel
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In an animal model, new evidence has been reported supporting the role of raet1e as an atherosclerosis-associated gene.
Our objective was to establish if raet1e polymorphisms are associated with the risk of developing premature coronary artery disease (CAD) or with the presence of cardiometabolic parameters.
After an informatic analysis, five polymorphisms were chosen and determined in 1158 patients with premature CAD and 1104 controls using 5′ exonuclease TaqMan genotyping assays.
Standardized questionnaires were applied to all participants to obtain family medical history, demographic information, history of nutritional habits, physical activity, alcohol consumption, and pharmacological treatment.
The functional effect of the rs7756850 polymorphism was analyzed by luciferase assays.
Under different models, adjusted by age, gender, body mass index, current smoking, and type 2 diabetes mellitus, the rs6925151 (OR=1.250, pheterozygote=0.026; OR=1.268, pcodominant1=0.034), rs9371533 (OR=1.255, pheterozygote=0.024), rs7756850 (OR=1.274, pheterozygote=0.016; OR=1.294, pcodominant1=0.031), and rs9383921 (OR=1.232, pheterozygote=0.037) polymorphisms were associated with increased risk of premature CAD.
When compared to the rs7756850 G allele, the C allele showed a decreased luciferase activity.
In premature CAD patients, associations with low levels of adiponectin, with a high presence of hypertension, and with high levels of gamma-glutamyltransferase and total cholesterol were observed.
In healthy controls, associations with a decrease in LDL pattern B, aspartate aminotransaminase, and hypo-α-lipoproteinemia were detected.
An association of the raet1e polymorphisms with an increased risk of developing premature CAD and with cardiometabolic parameters has been shown for the first time.
In addition, the functional effect of the rs7756850 polymorphism was defined.
American Psychological Association (APA)
Posadas-Sánchez, Rosalinda& Roque-Ramírez, Bladimir& Rodríguez-Pérez, José Manuel& Pérez-Hernández, Nonanzit& Fragoso, José Manuel& Villarreal-Molina, Teresa…[et al.]. 2018. Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203369
Modern Language Association (MLA)
Posadas-Sánchez, Rosalinda…[et al.]. Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203369
American Medical Association (AMA)
Posadas-Sánchez, Rosalinda& Roque-Ramírez, Bladimir& Rodríguez-Pérez, José Manuel& Pérez-Hernández, Nonanzit& Fragoso, José Manuel& Villarreal-Molina, Teresa…[et al.]. Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203369