Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6IL-10 Axis
Joint Authors
Vinícius da Silva, Marcos
de Oliveira, Carlo Jose Freire
Sales-Campos, Helioswilton
Catarino, Jonatas Da Silva
Trevisan, Rafael Obata
Roza, Guilherme Augusto
Menezes Silva, Luisa
Andrade-Silva, Leonardo Euripedes
Rodrigues, Virmondes
Machado, Juliana Reis
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Triatomines are known for their role as vectors of the causative agent of Chagas disease.
The occurrence of an arsenal of molecules in their saliva is able to suppress vertebrate immune responses.
Thus, it is reasonable to assume that the presence of molecules with therapeutic potential in their saliva is able to constrain inflammation in immune-mediated diseases.
Thus, mice were exposed to dextran sulfate sodium (DSS) in drinking water uninterruptedly during 6 consecutive days and treated with T.
lecticularia salivary gland extract (SGE) (3, 10, or 30 μg) or vehicle (saline) (n=6/group).
At the highest dose (30 μg), an improvement in clinical outcome and macroscopic aspects of the intestine were observed.
This observation was followed by amelioration in histopathological aspects in the colon especially when the doses of 10 and 30 μg were used.
Regardless of the concentration used, treatment with T.
lecticularia SGE significantly reduced the levels of the inflammatory cytokine IL-6 in the intestine.
The production of the anti-inflammatory cytokine IL-10 was positively impacted by the concentrations of 3 and 30 μg.
Our results suggest that the presence of molecules in the T.
lecticularia SGE is able to attenuate clinical outcome and colon shortening and improve intestinal architecture besides reducing the production of IL-6 and inducing a local production of IL-10 in the intestine.
American Psychological Association (APA)
Sales-Campos, Helioswilton& Catarino, Jonatas Da Silva& Roza, Guilherme Augusto& Trevisan, Rafael Obata& Menezes Silva, Luisa& Machado, Juliana Reis…[et al.]. 2018. Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6IL-10 Axis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203381
Modern Language Association (MLA)
Sales-Campos, Helioswilton…[et al.]. Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6IL-10 Axis. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203381
American Medical Association (AMA)
Sales-Campos, Helioswilton& Catarino, Jonatas Da Silva& Roza, Guilherme Augusto& Trevisan, Rafael Obata& Menezes Silva, Luisa& Machado, Juliana Reis…[et al.]. Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6IL-10 Axis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203381