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Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice
Joint Authors
Connes, Philippe
Pialoux, Vincent
Gouraud, Etienne
Charrin, Emmanuelle
Dubé, John J.
Ofori-Acquah, Solomon F.
Martin, Cyril
Skinner, Sarah
Chatel, Benjamin
Boreau, Anaelle
Messonnier, Laurent A.
Hautier, Christophe
Faes, Camille
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is a key feature in the pathophysiology of sickle cell disease.
Endurance training has been shown to reduce oxidative stress in the heart and the liver of sickle mice.
However, the effects of endurance training on skeletal muscles, which are major producers of reactive oxygen species during exercise, are currently unknown.
The aim of this study was to evaluate the effect of sickle genotype on prooxidant/antioxidant response to individualized endurance training in skeletal muscles of sickle mice.
Healthy and homozygous Townes sickle mice were divided into trained or sedentary groups.
Maximal aerobic speed and V̇O2 peak were determined using an incremental test on a treadmill.
Trained mice ran at 40% to 60% of maximal aerobic speed, 1 h/day, 5 days/week for 8 weeks.
Oxidative stress markers, prooxidant/antioxidant response, and citrate synthase enzyme activities were assessed in the gastrocnemius, in the plantaris, and in the soleus muscles.
Maximal aerobic speed and V̇O2 peak were significantly reduced in sickle compared to healthy mice (-57% and -17%; p<0.001).
NADPH oxidase, superoxide dismutase, and catalase activities significantly increased after training in the gastrocnemius of sickle mice only.
A similar trend was observed for citrate synthase activity in sickle mice (p=0.06).
In this study, we showed an adaptive response to individualized endurance training on the prooxidant/antioxidant balance in the gastrocnemius, but neither in the plantaris nor in the soleus of trained sickle mice, suggesting an effect of sickle genotype on skeletal muscle response to endurance treadmill training.
American Psychological Association (APA)
Gouraud, Etienne& Charrin, Emmanuelle& Dubé, John J.& Ofori-Acquah, Solomon F.& Martin, Cyril& Skinner, Sarah…[et al.]. 2019. Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203391
Modern Language Association (MLA)
Gouraud, Etienne…[et al.]. Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203391
American Medical Association (AMA)
Gouraud, Etienne& Charrin, Emmanuelle& Dubé, John J.& Ofori-Acquah, Solomon F.& Martin, Cyril& Skinner, Sarah…[et al.]. Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203391