Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension
Joint Authors
Rzymski, Piotr
Araszkiewicz, Aleksander
Sławek-Szmyt, Sylwia
Jankiewicz, Stanisław
Mularek-Kubzdela, Tatiana
Smukowska-Gorynia, Anna
Marcinkowska, Justyna
Poniedziałek, Barbara
Komosa, Anna
Cieslewicz, Artur
Janus, Magdalena
Tomaszewska-Krajniak, Iga
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress is regarded to play a crucial role in the pathophysiology of pulmonary arterial hypertension (PAH) and inoperable chronic thromboembolic pulmonary hypertension (CTEPH).
This study evaluated the prognostic value of serum oxidative stress markers (malondialdehyde (MDA), total antioxidant capacity (TAC), catalase activity (CAT), and superoxide activity (SOD)) in patients with PAH and CTEPH (n=45).
During 13 months of follow-up (median 9 months), clinical deterioration occurred in 14 patients (including 2 deaths).
On the Cox regression analysis, MDA, TAC, and CAT were associated with clinical deterioration (p=0.0068, HR=1.42, 95% CI: 1.10-1.82; p=0.0038, HR=0.033, 95% CI: 0.0032-0.33; and p=0.046, HR=0.20, 95% CI: 0.04-0.98, respectively).
There was no significant difference in SOD (p=0.53, HR=0.97, 95% CI: 0.87-1.08).
The cut-off value derived from ROC curve analysis was 3.79 μM (p=0.0048, AUC=0.76, 95% CI: 0.62-0.91) for MDA, 0.49 mM (p=0.027, AUC=0.71, 95% CI: 0.18-0.47) for TAC, and 1.34 U/L (p=0.029, AUC=0.71, 95% CI: 0.55-0.86) for CAT.
MDA in the group with deterioration was higher (p=0.0041), while TAC as well as CAT were lower (p=0.027 and p=0.028, respectively) when compared to stable patients.
Survival without clinical deterioration was significantly longer in patients with lower MDA (p=0.037, HR=0.37, 95% CI: 0.12-1.14, log-rank), higher TAC (p=0.0018, HR=0.19, 95% CI: 0.06-0.60, log-rank), and higher CAT (p=0.044, HR=0.31 95% CI: 0.11-0.88, log-rank).
Markers of oxidative stress such as MDA, TAC, and CAT were associated with adverse clinical outcomes in patients with PAH and inoperable or residual CTEPH.
American Psychological Association (APA)
Smukowska-Gorynia, Anna& Rzymski, Piotr& Marcinkowska, Justyna& Poniedziałek, Barbara& Komosa, Anna& Cieslewicz, Artur…[et al.]. 2019. Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1203406
Modern Language Association (MLA)
Smukowska-Gorynia, Anna…[et al.]. Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1203406
American Medical Association (AMA)
Smukowska-Gorynia, Anna& Rzymski, Piotr& Marcinkowska, Justyna& Poniedziałek, Barbara& Komosa, Anna& Cieslewicz, Artur…[et al.]. Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1203406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203406