Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease
Joint Authors
Wu, Dongdong
Ji, Xinying
Wang, Da-Yong
Li, Hui-Min
Guo, Jian-Cheng
Duan, Shao-Feng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as a toxic gas and environment pollutant.
However, increasing evidence suggests that H2S acts as a novel gasotransmitter and plays important roles in a variety of physiological and pathological processes in mammals.
H2S is involved in many hepatic functions, including the regulation of oxidative stress, glucose and lipid metabolism, vasculature, mitochondrial function, differentiation, and circadian rhythm.
In addition, H2S contributes to the pathogenesis and treatment of a number of liver diseases, such as hepatic fibrosis, liver cirrhosis, liver cancer, hepatic ischemia/reperfusion injury, nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, hepatotoxicity, and acute liver failure.
In this review, the biosynthesis and metabolism of H2S in the liver are summarized and the role and mechanism of H2S in liver health and disease are further discussed.
American Psychological Association (APA)
Wu, Dongdong& Wang, Da-Yong& Li, Hui-Min& Guo, Jian-Cheng& Duan, Shao-Feng& Ji, Xinying. 2019. Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203419
Modern Language Association (MLA)
Wu, Dongdong…[et al.]. Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203419
American Medical Association (AMA)
Wu, Dongdong& Wang, Da-Yong& Li, Hui-Min& Guo, Jian-Cheng& Duan, Shao-Feng& Ji, Xinying. Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203419