Low-Copy Number Polymorphism in DEFA1DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients
Joint Authors
Shu, Qiang
Zhao, Jialian
Gu, Qiang
Wang, Lifeng
Xu, Weize
Chu, Lihua
Wang, Ya
Li, Zhongwang
Wu, Shuijing
Xu, Jianguo
Hu, Zhiyong
Fang, Xiangming
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1–3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections.
To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAIs and 109 controls in the intensive care unit (ICU) and examined their DEFA1/DEFA3 CNVs.
DEFA1/DEFA3 copy number ranged from 2 to 16 per diploid genome in all 215 critically ill patients, with a median of 7 copies.
In HAIs, DEFA1/DEFA3 CNV varied from 2 to 12 with a median of 6, which was significantly lower than that in controls (2 to 16 with a median of 8, p=0.017).
Patients with lower DEFA1/DEFA3 copy number (CNV < 7) were far more common in HAIs than in controls (52.8% in HAIs versus 35.8% in controls; p=0.014; OR, 2.010; 95% CI, 1.164–3.472).
The area under the receiver operating characteristic (AUROC) of DEFA1/DEFA3 CNV combined with clinical characteristics to predict the incidence of HAIs was 0.763 (95% CI 0.700–0.827), showing strong predictive ability.
Therefore, lower DEFA1/DEFA3 copy number contributes to higher susceptibility to HAIs in critically ill patients, and DEFA1/DEFA3 CNV is a significant hereditary factor for predicting HAIs.
American Psychological Association (APA)
Zhao, Jialian& Gu, Qiang& Wang, Lifeng& Xu, Weize& Chu, Lihua& Wang, Ya…[et al.]. 2018. Low-Copy Number Polymorphism in DEFA1DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203428
Modern Language Association (MLA)
Zhao, Jialian…[et al.]. Low-Copy Number Polymorphism in DEFA1DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203428
American Medical Association (AMA)
Zhao, Jialian& Gu, Qiang& Wang, Lifeng& Xu, Weize& Chu, Lihua& Wang, Ya…[et al.]. Low-Copy Number Polymorphism in DEFA1DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203428