Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used
Joint Authors
Hermanowicz, Adam
Tylicka, Marzena
Dębek, Wojciech
Karpińska, Maria
Ostrowska, Halina
Matuszczak, Ewa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Surgical tissue damage and the accompanying inflammatory response lead to proteasome activation, initiation of damaged protein degradation, and induction of acute-phase inflammatory response.
The aim of this study was to investigate the rate of change in proteasome chymotrypsin-like (ChT-L) activity and C-reactive protein concentration depending on the degree of tissue damage and their correlation with prealbumin concentrations in children before and after abdominal surgery.
This experimental study included children who underwent abdominal surgery between 2015 and 2017.
Plasma prealbumin concentrations and C-reactive protein levels (CRP) were determined by standard biochemical laboratory procedures.
Proteasome activity was assessed using a Suc-Leu-Leu-Val-Tyr-AMC peptide substrate.
Elevation of plasma proteasome activity was noted in children after laparoscopic and open abdominal surgeries.
However, 20S proteasome activity in children undergoing conventional open surgery was significantly higher (P<0.05) than in patients subjected to laparoscopy.
At the same time, an increase in the CRP level was observed.
However, there was no correlation between C-reactive protein concentrations and the type of abdominal surgery while there was a correlation observed in the case of proteasomes.
Proteasome activity correlates with the degree of surgical tissue damage and prealbumin concentrations.
More invasive surgery leads to a stronger activation of the proteasome involved in removing proteins that were damaged due to the surgical procedure.
Proteasomes are more specific markers because there is a correlation between proteasome activity and the type of abdominal surgery in contrast to C-reactive protein concentrations which are not different in response to surgery performed in regard to ovarian cysts or cholelithiasis.
American Psychological Association (APA)
Tylicka, Marzena& Matuszczak, Ewa& Karpińska, Maria& Hermanowicz, Adam& Dębek, Wojciech& Ostrowska, Halina. 2018. Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203449
Modern Language Association (MLA)
Tylicka, Marzena…[et al.]. Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203449
American Medical Association (AMA)
Tylicka, Marzena& Matuszczak, Ewa& Karpińska, Maria& Hermanowicz, Adam& Dębek, Wojciech& Ostrowska, Halina. Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203449