Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery
Joint Authors
Castillo, E. C.
Elizondo-Montemayor, Leticia
Garcia-Rivas, Gerardo
Villarreal-Calderón, José R.
Cuéllar, Ricardo X.
Ramos-González, Martín R.
Rubio-Infante, Nestor
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Low-grade chronic inflammation plays a pivotal role among other pathophysiological mechanisms involved in obesity.
Innate and adaptive immune cells undergo systemic proinflammatory polarization that gives rise to an increased secretion of proinflammatory cytokines, which in turn leads to insulin resistance.
Bariatric surgery is currently the most effective treatment for obesity, as it brings on significant weight loss, glucose metabolism improvement, and a decrease in systemic inflammation biomarkers.
After bariatric surgery, several changes have been reported to occur in adaptive immunity, including reduction in CD4+ and CD8+ T cell counts, a decrease in the Th1/Th2 ratio, an increase in B regulatory cells, and reduction in proinflammatory cytokine secretion.
Overall, there seems to be a major shift in several lymphocyte populations from a proinflammatory to an anti-inflammatory phenotype.
Furthermore, increased antioxidant activity and reduced lipid and DNA oxidation products have been reported after bariatric surgery in circulating mononuclear cells.
This paper highlights the shift in the adaptive immune system in response to weight loss and improved insulin sensitivity, as well as the interplay between immunological and metabolic adaptations as a result of bariatric surgery.
Finally, based on data from research, we propose several mechanisms such as changes in adaptive immune cell phenotypes and their by-products, recruitment in adipose tissue, reduced oxidative stress, and modification in metabolic substrate availability as drivers to reduce low-grade chronic inflammation after bariatric surgery in severe obesity.
American Psychological Association (APA)
Villarreal-Calderón, José R.& Cuéllar, Ricardo X.& Ramos-González, Martín R.& Rubio-Infante, Nestor& Castillo, E. C.& Elizondo-Montemayor, Leticia…[et al.]. 2019. Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203451
Modern Language Association (MLA)
Villarreal-Calderón, José R.…[et al.]. Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203451
American Medical Association (AMA)
Villarreal-Calderón, José R.& Cuéllar, Ricardo X.& Ramos-González, Martín R.& Rubio-Infante, Nestor& Castillo, E. C.& Elizondo-Montemayor, Leticia…[et al.]. Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203451