Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease
Joint Authors
Luchena, Celia
Zuazo-Ibarra, Jone
Alberdi, Elena
Matute, Carlos
Capetillo-Zarate, Estibaliz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Synapse loss is an early manifestation of pathology in Alzheimer’s disease (AD) and is currently the best correlate to cognitive decline.
Microglial cells are involved in synapse pruning during development via the complement pathway.
Moreover, recent evidence points towards a key role played by glial cells in synapse loss during AD.
However, further contribution of glial cells and the role of neurons to synapse pathology in AD remain not well understood.
This review is aimed at comprehensively reporting the source and/or cellular localization in the CNS—in microglia, astrocytes, or neurons—of the triggering components (C1q, C3) of the classical complement pathway involved in synapse pruning in development, adulthood, and AD.
American Psychological Association (APA)
Luchena, Celia& Zuazo-Ibarra, Jone& Alberdi, Elena& Matute, Carlos& Capetillo-Zarate, Estibaliz. 2018. Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203460
Modern Language Association (MLA)
Luchena, Celia…[et al.]. Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203460
American Medical Association (AMA)
Luchena, Celia& Zuazo-Ibarra, Jone& Alberdi, Elena& Matute, Carlos& Capetillo-Zarate, Estibaliz. Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203460
