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Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease
Joint Authors
Juárez, Imelda
Reyes, José Luis
Vannan, Danielle T.
Eksteen, Bertus
Rodríguez, Tonathiu
González, Marisol Ibet
Mendoza, Alicia Vázquez
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide.
DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED.
Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality.
In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis.
Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury.
However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies.
The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes.
This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED.
American Psychological Association (APA)
Reyes, José Luis& Vannan, Danielle T.& Eksteen, Bertus& Juárez, Imelda& Rodríguez, Tonathiu& González, Marisol Ibet…[et al.]. 2018. Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203463
Modern Language Association (MLA)
Reyes, José Luis…[et al.]. Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203463
American Medical Association (AMA)
Reyes, José Luis& Vannan, Danielle T.& Eksteen, Bertus& Juárez, Imelda& Rodríguez, Tonathiu& González, Marisol Ibet…[et al.]. Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203463