Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease
Joint Authors
Fernández-Arroyo, Salvador
Cabre, Noemí
Baiges-Gaya, Gerard
Fibla, Montserrat
Joven, Jorge
Luciano-Mateo, Fedra
Martín-Paredero, Vicente
Menéndez, Javier A.
Camps, Jordi
Hernández-Aguilera, Anna
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peripheral artery disease (PAD) is a common disease affecting 20–25% of population over 60 years old.
Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease.
Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension.
We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach.
We found relevant associations between several metabolites (3-hydroxybutirate, aconitate, (iso)citrate, glutamate, and serine) with markers of oxidative stress and inflammation.
Metabolomic profiling also revealed that (iso)citrate and glutamate are metabolites with high ability to discriminate between healthy participants and PAD patients without symptoms.
Collectively, our data suggest that metabolomics provide significant information on the pathogenesis of PAD and useful biomarkers for the diagnosis and assessment of progression.
American Psychological Association (APA)
Hernández-Aguilera, Anna& Fernández-Arroyo, Salvador& Cabre, Noemí& Luciano-Mateo, Fedra& Baiges-Gaya, Gerard& Fibla, Montserrat…[et al.]. 2018. Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203483
Modern Language Association (MLA)
Hernández-Aguilera, Anna…[et al.]. Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203483
American Medical Association (AMA)
Hernández-Aguilera, Anna& Fernández-Arroyo, Salvador& Cabre, Noemí& Luciano-Mateo, Fedra& Baiges-Gaya, Gerard& Fibla, Montserrat…[et al.]. Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203483