Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology
Joint Authors
Rayego-Mateos, Sandra
Valdivielso, José Manuel
Kerr, Bredford
Morgado-Pascual, Jose Luis
Marchant, Vanessa
Rodrigues-Diez, Raul
Dolade, Nuria
Suarez-Alvarez, Beatriz
Ruiz-Ortega, Marta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society.
Chronic kidney disease (CKD) is characterized by persistent inflammation, fibrosis, and loss of renal function leading to end-stage renal disease.
Nowadays, CKD treatment has limited effectiveness underscoring the importance of the development of innovative therapeutic options.
Recent studies have identified how epigenetic modifications participate in the susceptibility to CKD and have explained how the environment interacts with the renal cell epigenome to contribute to renal damage.
Epigenetic mechanisms regulate critical processes involved in gene regulation and downstream cellular responses.
The most relevant epigenetic modifications that play a critical role in renal damage include DNA methylation, histone modifications, and changes in miRNA levels.
Importantly, these epigenetic modifications are reversible and, therefore, a source of potential therapeutic targets.
Here, we will explain how epigenetic mechanisms may regulate essential processes involved in renal pathology and highlight some possible epigenetic therapeutic strategies for CKD treatment.
American Psychological Association (APA)
Morgado-Pascual, Jose Luis& Marchant, Vanessa& Rodrigues-Diez, Raul& Dolade, Nuria& Suarez-Alvarez, Beatriz& Kerr, Bredford…[et al.]. 2018. Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1203493
Modern Language Association (MLA)
Morgado-Pascual, Jose Luis…[et al.]. Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1203493
American Medical Association (AMA)
Morgado-Pascual, Jose Luis& Marchant, Vanessa& Rodrigues-Diez, Raul& Dolade, Nuria& Suarez-Alvarez, Beatriz& Kerr, Bredford…[et al.]. Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1203493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203493