Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia
Joint Authors
Badran, Mohammad
Ayas, Najib
Abuyassin, Bisher
Golbidi, Saeid
Laher, Ismail
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia (CIH).
OSA is associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction and cardiovascular disease (CVD).
Alpha lipoic acid (ALA) is a potent antioxidant with anti-inflammatory properties.
We hypothesized that dietary ALA can improve endothelial function of mice exposed to CIH.
Methods.
Mice were exposed to either CIH or intermittent air (IA) and treated with dietary ALA (0.2% w/w) or a regular chow diet for 8 weeks.
Endothelial function, endothelial nitric oxide (eNOS) uncoupling, systemic oxidative stress, systemic inflammation, aortic expression of inflammatory cytokines, and antioxidant enzymes were measured after 8 weeks.
Results.
Mice exposed to CIH exhibited endothelial dysfunction accompanied by systemic oxidative stress and inflammation as well as increased aortic expression of inflammatory cytokines.
Furthermore, CIH led to eNOS uncoupling.
Treatment with dietary ALA reversed endothelial dysfunction in mice exposed to CIH, lowered systemic oxidative stress and inflammation, prevented the increases of inflammatory cytokine gene expression, increased the expression of antioxidant enzymes, and preserved eNOS in a coupled state.
Conclusion.
ALA attenuates endothelial dysfunction by preventing oxidative stress and inflammation and restoring nitric oxide bioavailability in mice exposed to CIH.
Our data suggests the potential beneficial use of ALA as adjunctive therapy in OSA.
American Psychological Association (APA)
Badran, Mohammad& Abuyassin, Bisher& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. 2019. Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203496
Modern Language Association (MLA)
Badran, Mohammad…[et al.]. Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1203496
American Medical Association (AMA)
Badran, Mohammad& Abuyassin, Bisher& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203496