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Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages
Joint Authors
Nakatsu, Yusuke
Asano, Tomoichiro
Sakoda, Hideyuki
Yamazaki, Hiroki
Kushiyama, Akifumi
Fujishiro, Midori
Yamamotoya, Takeshi
Kikuchi, Takako
Kaneko, Sunao
Tanaka, Hirotoshi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sex hormone-binding globulin (SHBG) is a serum protein released mainly by the liver, and a low serum level correlates with a risk for metabolic syndrome including diabetes, obesity, and cardiovascular events.
However, the underlying molecular mechanism(s) linking SHBG and metabolic syndrome remains unknown.
In this study, using adipocytes and macrophages, we focused on the in vitro effects of SHBG on inflammation as well as lipid metabolism.
Incubation with 20 nM SHBG markedly suppressed lipopolysaccharide- (LPS-) induced inflammatory cytokines, such as MCP-1, TNFα, and IL-6 in adipocytes and macrophages, along with phosphorylations of JNK and ERK.
Anti-inflammatory effects were also observed in 3T3-L1 adipocytes cocultured with LPS-stimulated macrophages.
In addition, SHBG treatment for 18 hrs or longer significantly induced the lipid degradation of differentiated 3T3-L1 cells, with alterations in its corresponding gene and protein levels.
Notably, these effects of SHBG were not altered by coaddition of large amounts of testosterone or estradiol.
In conclusion, SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome.
American Psychological Association (APA)
Yamazaki, Hiroki& Kushiyama, Akifumi& Sakoda, Hideyuki& Fujishiro, Midori& Yamamotoya, Takeshi& Nakatsu, Yusuke…[et al.]. 2018. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203519
Modern Language Association (MLA)
Yamazaki, Hiroki…[et al.]. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203519
American Medical Association (AMA)
Yamazaki, Hiroki& Kushiyama, Akifumi& Sakoda, Hideyuki& Fujishiro, Midori& Yamamotoya, Takeshi& Nakatsu, Yusuke…[et al.]. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203519