Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Joint Authors
Oliveira, Luana de Mendonça
Teixeira, Franciane Mouradian Emidio
Sato, Maria Notomi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses.
RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3+ inducible regulatory T cells, and induces gut-homing specificity in T cells.
Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases.
The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents.
Here, we review the effect of RA on innate and adaptive immunity with a special emphasis on inflammatory status.
American Psychological Association (APA)
Oliveira, Luana de Mendonça& Teixeira, Franciane Mouradian Emidio& Sato, Maria Notomi. 2018. Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1203521
Modern Language Association (MLA)
Oliveira, Luana de Mendonça…[et al.]. Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases. Mediators of Inflammation No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1203521
American Medical Association (AMA)
Oliveira, Luana de Mendonça& Teixeira, Franciane Mouradian Emidio& Sato, Maria Notomi. Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1203521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203521