The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus
Joint Authors
Mendoza-Pinto, Claudia
Carrasco, Mario García
Ruiz-Argüelles, Alejandro
Soto-Santillán, Pamela
González-Ramírez, Rebeca
López-Carmona, Ana Lidia
Munguía-Realpozo, Pamela
Etchegaray-Morales, Ivet
Méndez-Martínez, Socorro
Gálvez-Romero, José Luis
López-Colombo, Aurelio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The increase in cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is not fully explained by traditional CVD risk factors.
Regulatory T cells (Treg cells) are considered atheroprotective.
We investigated the relationship between the absolute number of different phenotypes of Treg cells and abnormal carotid intima-media thickness (IMT) in women with SLE.
Sixty-six women with SLE with no history of CV disease were included.
Carotid IMT was quantified by ultrasound.
Abnormal carotid IMT was defined as ≥0.8 mm and two groups were compared according to this definition.
Flow cytometry was used to analyze Foxp3 and Helios expression in peripheral blood CD4 T cells.
A significantly higher level of absolute CD4+CD25+FoxP3high T cells was present in patients with abnormal carotid IMT compared with those without (1.795±4.182 cells/μl vs.
0.274±0.784 cells/μl; p=0.003).
However, no correlations were found between any Treg cell phenotypes and carotid IMT.
Only the absolute number of CD4+CD45RA+FoxP3low T cells was significantly decreased in SLE patients with low HDL cholesterol compared with those with normal HDL cholesterol (0.609±2.362 cells/μl vs.
1.802±4.647 cells/μl; p=0.009 and 15.358±11.608 cells/μl vs.
28.274±34.139; p=0.012, respectively).
In conclusion, in SLE women, diminished levels of Treg cells based on flow cytometry were not a good indicator of abnormal carotid IMT.
American Psychological Association (APA)
Carrasco, Mario García& Soto-Santillán, Pamela& Mendoza-Pinto, Claudia& González-Ramírez, Rebeca& López-Carmona, Ana Lidia& Munguía-Realpozo, Pamela…[et al.]. 2018. The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203547
Modern Language Association (MLA)
Carrasco, Mario García…[et al.]. The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203547
American Medical Association (AMA)
Carrasco, Mario García& Soto-Santillán, Pamela& Mendoza-Pinto, Claudia& González-Ramírez, Rebeca& López-Carmona, Ana Lidia& Munguía-Realpozo, Pamela…[et al.]. The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203547