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Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn’s Disease
Joint Authors
Dahlerup, Jens F.
Dige, Anders
Agnholt, Jørgen
Magnusson, Maria K.
Uhrenholt, Claus
Rasmussen, Tue Kruse
Kragstrup, Tue
Öhman, Lena
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
T helper 17 (Th17) cells produce interleukin (IL) 17-A.
In addition, Th17 cells produce IL-21 and IL-22.
Th17 cells have a disease-promoting role in Crohn’s disease (CD).
We investigated the effects of anti-TNFα treatment on mucosal gene expression (qPCR) of IL-17A, IL-21, and IL-22 as well as on the frequency of lamina propria (LP) T cell subsets producing these cytokines (flow cytometry) in 12 active CD patients before and after 4 weeks of anti-TNFα treatment with adalimumab.
At baseline, in inflamed mucosa we found increased gene expression of IL-17A and IL-22 but not IL-21 when compared to noninflamed mucosa.
There were increased frequencies of IL-21-producing LP T cells but no differences in the frequencies of IL-17A- or IL-22-producing LP T cells when comparing inflamed versus noninflamed mucosa at baseline.
There were no changes in the mucosal gene expression of IL-17A, IL-21, and IL-22 or the frequencies of IL-17A-, IL-21- and IL-22-producing LP T cell subsets between baseline and following 4 weeks of adalimumab initiation.
Our results do not support the hypothesis that anti-TNFα treatment has an early effect on the mucosal levels of IL-17A, IL-21, and IL-22 or LP T cell production of these cytokines in CD.
American Psychological Association (APA)
Dige, Anders& Magnusson, Maria K.& Uhrenholt, Claus& Rasmussen, Tue Kruse& Kragstrup, Tue& Öhman, Lena…[et al.]. 2018. Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn’s Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203552
Modern Language Association (MLA)
Dige, Anders…[et al.]. Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn’s Disease. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203552
American Medical Association (AMA)
Dige, Anders& Magnusson, Maria K.& Uhrenholt, Claus& Rasmussen, Tue Kruse& Kragstrup, Tue& Öhman, Lena…[et al.]. Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn’s Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203552