Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
Joint Authors
Shrishrimal, Shashank
Kosmacek, Elizabeth A.
Oberley-Deegan, Rebecca E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins.
One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure.
Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts.
Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF.
Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.
American Psychological Association (APA)
Shrishrimal, Shashank& Kosmacek, Elizabeth A.& Oberley-Deegan, Rebecca E.. 2019. Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1203557
Modern Language Association (MLA)
Shrishrimal, Shashank…[et al.]. Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-27.
https://search.emarefa.net/detail/BIM-1203557
American Medical Association (AMA)
Shrishrimal, Shashank& Kosmacek, Elizabeth A.& Oberley-Deegan, Rebecca E.. Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1203557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203557