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The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol
Joint Authors
Karolczak, Kamil
Watala, Cezary
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Melatonin may be considered a cardioprotective agent.
Since atherogenesis is partly associated with the metabolism of lipoproteins, it seems plausible that melatonin affects cardiovascular risk by modulating the metabolism of cholesterol and its subfractions.
Moreover, cholesterol-driven atherogenesis can be hypothetically reduced by melatonin, mainly due to the minimalization of harmful reactions triggered in the cardiovascular system by the reactive oxygen species-induced toxic derivatives of cholesterol.
In this review, we attempted to summarize the available data on the hypolipemizing effects of melatonin, with some emphasis on the molecular mechanisms underlying these reactions.
We aimed to attract readers’ attention to the numerous gaps of knowledge present in the reviewed field and the essential irrelevance between the findings originating from different sources: clinical observations and in vitro mechanistic and molecular studies, as well as preclinical experiments involving animal models.
Overall, such inconsistencies make it currently impossible to give a reliable opinion on the action of melatonin on the metabolism of lipoproteins.
American Psychological Association (APA)
Karolczak, Kamil& Watala, Cezary. 2019. The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1203607
Modern Language Association (MLA)
Karolczak, Kamil& Watala, Cezary. The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1203607
American Medical Association (AMA)
Karolczak, Kamil& Watala, Cezary. The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1203607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203607