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IL-33IL-31 Axis: A Potential Inflammatory Pathway
Joint Authors
Navarra, Michele
Gangemi, Sebastiano
Casciaro, Marco
Ventura Spagnolo, Elvira
Di Salvo, Eleonora
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytokines play an important role in the regulation of the immune system (adaptive and innate).
Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases.
IL-31 and IL-33 are still considered novel cytokines.
IL-31 controls signalling and regulates a huge amount of biological functions: it induces proinflammatory cytokines, regulates cell proliferation, and is involved also in tissue remodelling.
On the other hand, IL-33 has been identified as an “alarmin” released from the epithelial cells and from different human tissues and organs after a damage following, that is, an inflammatory process.
The aim of this literature review is to strengthen the hypothesis about an IL-31/IL-33 axis by evaluating the most recent studies linking these two cytokines.
Literature data showed that, in many cases, IL-31 and IL-33 are linked to each other and that their expression is correlated with disease severity.
The presence of one interleukin might stimulate the induction of the other, amplifying inflammation and the consequent detrimental processes.
In a near future, influencing their balance could be helpful in modulating the first responses of the immune system in order to prevent the development of many inflammation-related diseases.
American Psychological Association (APA)
Di Salvo, Eleonora& Ventura Spagnolo, Elvira& Casciaro, Marco& Navarra, Michele& Gangemi, Sebastiano. 2018. IL-33IL-31 Axis: A Potential Inflammatory Pathway. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203608
Modern Language Association (MLA)
Di Salvo, Eleonora…[et al.]. IL-33IL-31 Axis: A Potential Inflammatory Pathway. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1203608
American Medical Association (AMA)
Di Salvo, Eleonora& Ventura Spagnolo, Elvira& Casciaro, Marco& Navarra, Michele& Gangemi, Sebastiano. IL-33IL-31 Axis: A Potential Inflammatory Pathway. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1203608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203608