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Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis
Joint Authors
Spinelli, F. R.
Valesini, Guido
Conti, Fabrizio
Lucchino, Bruno
Di Franco, Manuela
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cardiovascular disease is the main cause of morbidity and mortality in rheumatoid arthritis (RA).
Despite the advent on new drugs targeting the articular manifestations, the burden of cardiovascular disease is still an unmet need in the management of RA.
The pathophysiology of accelerated atherosclerosis associated to RA is not yet fully understood, and reliable and specific markers of early cardiovascular involvement are still lacking.
Asymmetric dimethylarginine is gaining attention for its implication in the pathogenesis of endothelial dysfunction and as biomarkers of subclinical atherosclerosis.
Moreover, the metabolic pathway of methylarginines offers possible targets for therapeutic interventions to decrease the cardiovascular risk.
The purpose of this review is to describe the main causes of increased methylarginine levels in RA, their implication in accelerated atherosclerosis, the possible role as biomarkers of cardiovascular risk, and finally the available data on current pharmacological treatment.
American Psychological Association (APA)
Di Franco, Manuela& Lucchino, Bruno& Conti, Fabrizio& Valesini, Guido& Spinelli, F. R.. 2018. Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203611
Modern Language Association (MLA)
Di Franco, Manuela…[et al.]. Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1203611
American Medical Association (AMA)
Di Franco, Manuela& Lucchino, Bruno& Conti, Fabrizio& Valesini, Guido& Spinelli, F. R.. Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203611