The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity
Joint Authors
Zalewska, Anna
Choromańska, Barbara
Myśliwiec, Piotr
Łuba, Magdalena
Wojskowicz, Piotr
Myśliwiec, Hanna
Choromańska, Katarzyna
Dadan, Jacek
Maciejczyk, Mateusz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this pathbreaking study, we evaluated nitrosative stress in morbidly obese patients with and without metabolic syndrome.
62 women with class 3 obesity (BMI>40 kg/m2) were divided into three subgroups: obese patients (OB), obese patients with hypertension (OB+HYP), and obese patients with metabolic syndrome (OB+MS).
In comparison to the lean patients, OB had increased levels of serum myeloperoxidase (MPO), plasma nitric oxide (NO), S-nitrosothiols, and peroxynitrite (ONOO−), as well as nitrotyrosine, while oxidized glutathione (GSSG) rose only in OB+HYP group.
Interestingly, ONOO− was significantly higher in OB+HYP and OB+MS as compared to OB group, while MPO only in OB+MS group.
OB+MS had greater nitrotyrosine and S-nitrosothiol values than OB+HYP.
Moreover, peroxynitrite could differentiate OB from OB+HYP and OB+MS (AUC 0.9292; p<0.0001; 87.5% sensitivity, 90% specificity) as well as between OB and OB+MS group (AUC 0.9125; p<0.0001; 81.25% sensitivity, 83.33%).
In conclusion, we showed that MPO activity, NO formation, and nitrosative damage to proteins parallel the progression of metabolic disturbances of obesity.
Evaluation of ONOO− concentrations may help predict the development of hypertension and metabolic syndrome in patients with morbid obesity; however, longer-term studies are required for larger numbers of patients.
American Psychological Association (APA)
Choromańska, Barbara& Myśliwiec, Piotr& Łuba, Magdalena& Wojskowicz, Piotr& Myśliwiec, Hanna& Choromańska, Katarzyna…[et al.]. 2020. The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203621
Modern Language Association (MLA)
Choromańska, Barbara…[et al.]. The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203621
American Medical Association (AMA)
Choromańska, Barbara& Myśliwiec, Piotr& Łuba, Magdalena& Wojskowicz, Piotr& Myśliwiec, Hanna& Choromańska, Katarzyna…[et al.]. The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203621