Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1
Joint Authors
Lu, Min
Tan, Lin
Zhou, Xiao-Gang
Yang, Zhong-Lin
Zhu, Qing
Chen, Jian-Ning
Wu, Gui-Sheng
Luo, Huai-Rong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed, sunflower seeds, and sesame seeds.
Among the beneficial pharmacological activities of SDG on health, many are age related, such as anticancer, antidiabetes, antioxidant, and neuroprotective effects.
Thus, we investigated if SDG had an effect on antiaging in Caenorhabditis elegans (C.
elegans).
Our results showed that SDG could extend the lifespan of C.
elegans by up to 22.0%, delay age-related decline of body movement, reduce the lethality of heat and oxidative stress, alleviate dopamine neurodegeneration induced by 6-hydroxydopamine (6-OHDA), and decrease the toxicity of Aβ protein in C.
elegans.
SDG could increase the expression of the downstream genes of DAF-16, DAF-12, NHR-80, and HSF-1 at mRNA level.
SDG could not extend the lifespan of mutants from genes daf-16, hsf-1, nhr-80, daf-12, glp-1, eat-2, and aak-2.
The above results suggested that SDG might enhance the stress resistance, delay the progression of aging-related diseases, and extend the lifespan of C.
elegans via DAF-16 and HSF-1.
American Psychological Association (APA)
Lu, Min& Tan, Lin& Zhou, Xiao-Gang& Yang, Zhong-Lin& Zhu, Qing& Chen, Jian-Ning…[et al.]. 2020. Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203654
Modern Language Association (MLA)
Lu, Min…[et al.]. Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203654
American Medical Association (AMA)
Lu, Min& Tan, Lin& Zhou, Xiao-Gang& Yang, Zhong-Lin& Zhu, Qing& Chen, Jian-Ning…[et al.]. Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203654