Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREBBDNF Pathway in Alloxan-Induced Diabetic Mice
Joint Authors
Yoo, Jae-Myung
Min, A Young
Sok, Dai-Eun
Kim, Mee Ree
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although mulberry fruit has various beneficial effects, its effect on diabetes-related dementia remains unknown.
We investigated whether the ethyl acetate fraction of ethanolic extract of mulberry fruit (MFE) could alleviate biochemical and behavioral deficits in alloxan-induced diabetic mice.
In the diabetic mice, MFE considerably abolished multiple deficits, e.g., body weight reduction; water and food intake increase; and hyperglycemia, hyperlipidemia, hypoinsulinism, and hypertrophy of the liver, kidneys, spleen, and brain.
A 200 mg/kg MFE dose reduced malondialdehyde levels and improved antioxidant enzyme activity in the liver, kidney, and brain tissues.
MFE attenuated hyperglycemia-induced memory impairments and acetylcholine deprivation, protected neuronal cells in CA1 and CA3 regions via p-CREB/BDNF pathway activation, and reduced amyloid-β precursor protein and p-Tau expressions in the brain tissue.
In conclusion, MFE exerts antidiabetic and neuroprotective effects by upregulating antioxidative activities and p-CREB/BDNF pathway in chronic diabetes.
Therefore, MFE may be used as a therapeutic agent for diabetes and diabetic neurodegenerative diseases.
American Psychological Association (APA)
Min, A Young& Yoo, Jae-Myung& Sok, Dai-Eun& Kim, Mee Ree. 2020. Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREBBDNF Pathway in Alloxan-Induced Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203662
Modern Language Association (MLA)
Min, A Young…[et al.]. Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREBBDNF Pathway in Alloxan-Induced Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203662
American Medical Association (AMA)
Min, A Young& Yoo, Jae-Myung& Sok, Dai-Eun& Kim, Mee Ree. Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREBBDNF Pathway in Alloxan-Induced Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203662