Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption
Joint Authors
Pereira da Silva, Alda
Bicho, Manuel
Costa, Maria do Céu
Aguiar, Laura
Matos, Andreia
Gil, Ângela
Gorjão-Clara, J.
Polónia, Jorge
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Cardiovascular risk (CVR) underlies aging process and longevity.
Previous work points to genetic and environmental factors associated with this risk.
Objectives.
The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity.
Methods.
A case-control study involving 521 both gender individuals, 253 centenarians (100.26±1.98 years), and 268 controls (67.51±3.25 years), low (LCR, n=107) and high (HCR, n=161) CVR.
Hypertension, diabetes, obesity (BMI, kg·m-2), and impaired kidney function were defined according to standard criteria.
CVR was calculated using Q risk®.
DNA was genotyping (ACE-rs4646994, AGT-rs4762, AGR1-rs5182, GRK4-rs2960306, GRK4-rs1024323, NOS3-rs1799983, and SLC12A3-rs13306673) through iPlex-MassARRAY®, read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE®.
Results.
Antilongevity factors consisted (OR 95% CI, p<0.05) BMI 1.558 (1.445-1.680), hypertension 2.358 (1.565-3.553), smoking habits 4.528 (2.579-7.949), diabetes 5.553 (2.889-10.675), hypercholesterolemia 1.016 (1.010-1.022), and regular consumption of red meat 22.363 (13.987-35.755).
Genetic aspects particularly for HCR individuals ACE II (OR: 3.96 (1.83-8.56), p<0.0001) and NOS3 TT (OR: 3.11 (1.70-5.70), p<0.0001) genotypes were also risk associate.
Obesity, smoking, hypercholesterolemia, and frequent consumption of red meat have an additive action to hypertension in the longevity process.
There was a synergistic interaction between the endothelial NOS3 genotypes and the severity of arterial hypertension.
An epistatic interaction between functional genetic variants of GRK4 and angiotensinogen was also observed.
Conclusions.
Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians.
Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.
American Psychological Association (APA)
Pereira da Silva, Alda& Costa, Maria do Céu& Aguiar, Laura& Matos, Andreia& Gil, Ângela& Gorjão-Clara, J.…[et al.]. 2020. Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203664
Modern Language Association (MLA)
Pereira da Silva, Alda…[et al.]. Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1203664
American Medical Association (AMA)
Pereira da Silva, Alda& Costa, Maria do Céu& Aguiar, Laura& Matos, Andreia& Gil, Ângela& Gorjão-Clara, J.…[et al.]. Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203664