Upregulation of Plasminogen Activator Inhibitor-1 in Irradiated Recipient Arteries and Veins from Free Tissue Transfer Reconstruction in Cancer Patients
Joint Authors
Eriksson, Bjorn O.
Gahm, Caroline
Halle, Martin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Clinical studies have shown that radiotherapy can induce vascular disease at the site of exposure but is usually not clinically evident until years after treatment.
We have studied irradiated human arteries and veins to better understand the underlying biology in search of future treatments.
The aim was to investigate whether radiotherapy contributed to a sustained expression of plasminogen activator inhibitor-1 (PAI-1) in human arteries and veins.
Methods.
Irradiated arteries and veins were harvested, together with unirradiated control vessels, from patients undergoing free tissue transfer reconstruction at a median time of 90 weeks [5–650] following radiation exposure.
Differential gene expression of PAI-1 was analysed, together with immunohistochemistry (IHC) and immunofluorescence (IF).
Results.
PAI-1 gene expression was increased in both arteries (p=0.012) and veins (p<0.001) in irradiated compared to unirradiated control vessels.
IHC and IF indicated that cells expressing PAI-1 were located in the adventitia of both arteries and veins and colocalized with cells positive for CD68, CD45, and α-SMA in arteries and with CD45 and α-SMA in veins.
Conclusion.
The current study shows a sustained upregulation of PAI-1 in both arteries and veins after exposure to ionizing radiation, indicating a chronic inflammation mainly in the adventitia.
We believe that the results contribute to further understanding of radiation-induced vascular disease, where targeting PAI-1 may be a potential treatment.
American Psychological Association (APA)
Eriksson, Bjorn O.& Gahm, Caroline& Halle, Martin. 2018. Upregulation of Plasminogen Activator Inhibitor-1 in Irradiated Recipient Arteries and Veins from Free Tissue Transfer Reconstruction in Cancer Patients. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203678
Modern Language Association (MLA)
Eriksson, Bjorn O.…[et al.]. Upregulation of Plasminogen Activator Inhibitor-1 in Irradiated Recipient Arteries and Veins from Free Tissue Transfer Reconstruction in Cancer Patients. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203678
American Medical Association (AMA)
Eriksson, Bjorn O.& Gahm, Caroline& Halle, Martin. Upregulation of Plasminogen Activator Inhibitor-1 in Irradiated Recipient Arteries and Veins from Free Tissue Transfer Reconstruction in Cancer Patients. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203678