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Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates
Joint Authors
Choi, Byung Yoon
Shim, Ye Ji
Park, Kyo Hoon
Lee, Hyunju
Jung, Young Mi
Kim, Yu Mi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
We aimed to determine whether elevated levels of various inflammatory and immune proteins in umbilical cord blood are associated with an increased risk of newborn hearing screening (NHS) test failure in preterm neonates.
Methods.
This retrospective cohort study included 127 premature singleton infants who were born at ≤33.6 weeks.
Umbilical cord plasma at birth was assayed for interleukin (IL)-6, complement C3a and C5a, matrix metalloproteinase (MMP)-9, macrophage colony-stimulating factor (M-CSF), and endostatin levels using ELISA kits.
Neonatal blood C-reactive protein (CRP) levels were measured within 2 hours of birth.
The primary outcome measure was a uni- or bilateral refer result on an NHS test.
Univariate and multivariate analyses were applied.
Results.
Fifteen (11.8%) infants failed the NHS test.
In the univariate analyses, high IL-6 and low C3a levels in umbilical cord plasma, funisitis, and an elevated CRP level (>5 mg/L) in the immediate postnatal period were significantly associated with NHS test failure.
However, the levels of umbilical cord plasma MMP-9, C5a, M-CSF, and endostatin were not significantly different between infants who passed and those who failed the NHS test.
Multiple logistic regression analyses indicated that elevated umbilical cord plasma C3a levels were independently associated with a reduced risk of NHS test failure, whereas elevated levels of umbilical cord plasma IL-6 and high CRP levels in the immediate postnatal period were significantly associated with NHS test failure.
Conclusions.
Our data demonstrated that in preterm neonates, a systemic fetal inflammatory response reflected by umbilical cord plasma IL-6 and immediate postnatal CRP levels may contribute to the risk for NHS test failure, whereas the changes in complement activation fragments initiated in utero may have protective effect of hearing screen failure.
American Psychological Association (APA)
Shim, Ye Ji& Choi, Byung Yoon& Park, Kyo Hoon& Lee, Hyunju& Jung, Young Mi& Kim, Yu Mi. 2018. Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203734
Modern Language Association (MLA)
Shim, Ye Ji…[et al.]. Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203734
American Medical Association (AMA)
Shim, Ye Ji& Choi, Byung Yoon& Park, Kyo Hoon& Lee, Hyunju& Jung, Young Mi& Kim, Yu Mi. Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203734