Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy
Joint Authors
Aguilar-Alonso, Patricia
Reyes-Leyva, Julio
Cotzomi-Ortega, Israel
Maycotte, Paola
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions.
Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammation, intercellular signaling, and cancer progression.
The role of autophagy in cancer depends on the stage of tumorigenesis, serving a tumor-suppressor role before transformation and a tumor-survival function once a tumor is established.
We review recent evidence demonstrating the complexity of autophagy regulation during cancer, considering the interaction of autophagy with protein secretion pathways.
Autophagy manipulation during cancer treatment is likely to affect protein secretion andinter-cellular signaling either to the neighboring cancer cells or to the antitumoral immune response.
This will be an important consideration during cancer therapy since several clinical trials are trying to manipulate autophagy in combination with chemotherapy for the treatment of diverse types of cancers.
American Psychological Association (APA)
Cotzomi-Ortega, Israel& Aguilar-Alonso, Patricia& Reyes-Leyva, Julio& Maycotte, Paola. 2018. Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1203741
Modern Language Association (MLA)
Cotzomi-Ortega, Israel…[et al.]. Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy. Mediators of Inflammation No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1203741
American Medical Association (AMA)
Cotzomi-Ortega, Israel& Aguilar-Alonso, Patricia& Reyes-Leyva, Julio& Maycotte, Paola. Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1203741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203741