Changes in Redox Signaling in the Skeletal Muscle with Aging
Joint Authors
Csernoch, László
Dux, László
Szentesi, Péter
Keller-Pintér, Anikó
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality).
Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs.
Mitochondrial dysfunction and increased oxidative stress are the central driving forces for age-related skeletal muscle abnormalities.
The increased oxidative stress in the aged muscle can lead to altered excitation-contraction coupling and calcium homeostasis.
Furthermore, apoptosis-mediated fiber loss, atrophy of the remaining fibers, dysfunction of the satellite cells (muscle stem cells), and concomitant impaired muscle regeneration are also the consequences of increased oxidative stress, leading to a decrease in muscle mass, strength, and function of the aged muscle.
Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy.
American Psychological Association (APA)
Szentesi, Péter& Csernoch, László& Dux, László& Keller-Pintér, Anikó. 2019. Changes in Redox Signaling in the Skeletal Muscle with Aging. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203748
Modern Language Association (MLA)
Szentesi, Péter…[et al.]. Changes in Redox Signaling in the Skeletal Muscle with Aging. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1203748
American Medical Association (AMA)
Szentesi, Péter& Csernoch, László& Dux, László& Keller-Pintér, Anikó. Changes in Redox Signaling in the Skeletal Muscle with Aging. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203748