Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)
Joint Authors
Gonzalez, Andrea
Huerta-Salgado, Camila
Orozco-Aguilar, Josué
Aguirre, Francisco
Tacchi, Franco
Simon, Felipe
Cabello-Verrugio, Claudio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum.
These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more aggressive form of the disease characterized by steatosis, inflammatory status, and varying liver degrees fibrosis.
NAFLD is the most prevalent chronic liver disease worldwide.
The causes of NAFLD are diverse and include genetic and environmental factors.
The presence of NASH is strongly associated with cirrhosis development and hepatocellular carcinoma, two conditions that require liver transplantation.
The liver alterations during NAFLD are well described.
Interestingly, this pathological condition also affects other critical tissues and organs, such as skeletal muscle and even the cardiovascular, renal, and nervous systems.
Oxidative stress (OS) is a harmful state present in several chronic diseases, such as NAFLD.
The purpose of this review is to describe hepatic and extrahepatic dysfunctions in NAFLD.
We will also review the influence of OS on the physiopathological events that affect the critical function of the liver and peripheral tissues.
American Psychological Association (APA)
Gonzalez, Andrea& Huerta-Salgado, Camila& Orozco-Aguilar, Josué& Aguirre, Francisco& Tacchi, Franco& Simon, Felipe…[et al.]. 2020. Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD). Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1203773
Modern Language Association (MLA)
Gonzalez, Andrea…[et al.]. Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD). Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1203773
American Medical Association (AMA)
Gonzalez, Andrea& Huerta-Salgado, Camila& Orozco-Aguilar, Josué& Aguirre, Francisco& Tacchi, Franco& Simon, Felipe…[et al.]. Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD). Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1203773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203773