Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity
Joint Authors
Xu, Jin-Wen
Zhang, Q. G.
Wang, S. R.
Chen, X. M.
Guo, H. N.
Ling, Shuang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition.
Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction.
However, the mechanism through which it is beneficial is unclear.
In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity.
We found that DG administration decreased infarct size and cardiomyocyte apoptosis and improved left ventricular ejection fraction, fractional shortening, end-systolic volume index, end-systolic diameter, and carotid arterial blood flow output in rats.
DG administration also improved hemorheological parameters, myocardial damage biomarkers, and oxidative stress indexes.
The findings showed that DG administration inhibited neutrophil infiltration and reduced the serum interleukin-1 beta (IL-1β) level and myocardial IL-1β maturation.
Moreover, DG administration inhibited caspase-1 activity and activated adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in rat hearts.
These results suggested that DG administration inhibits inflammasome activity and IL-1β release through the AMPK pathway.
Our findings support the clinical efficacy of DG and partially reveal its mechanism, which is beneficial for understanding the therapeutic effects of this protective traditional Chinese patent drug.
American Psychological Association (APA)
Zhang, Q. G.& Wang, S. R.& Chen, X. M.& Guo, H. N.& Ling, Shuang& Xu, Jin-Wen. 2018. Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203777
Modern Language Association (MLA)
Zhang, Q. G.…[et al.]. Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1203777
American Medical Association (AMA)
Zhang, Q. G.& Wang, S. R.& Chen, X. M.& Guo, H. N.& Ling, Shuang& Xu, Jin-Wen. Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1203777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203777