Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity
Joint Authors
Fayyad-Kazan, Mohammad
Fayyad-Kazan, Hussein
Rachidi, Walid
Rezvani, Hamid Reza
Kobaisi, F.
Fayyad, N.
Sulpice, E.
Gidrol, X.
Badran, Bassam
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The continuous exposure of the human body’s cells to radiation and genotoxic stresses leads to the accumulation of DNA lesions.
Fortunately, our body has several effective repair mechanisms, among which is nucleotide excision repair (NER), to counteract these lesions.
NER includes both global genome repair (GG-NER) and transcription-coupled repair (TC-NER).
Deficiencies in the NER pathway underlie the development of several DNA repair diseases, such as xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD).
Deficiencies in GG-NER and TC-NER render individuals to become prone to cancer and neurological disorders, respectively.
Therefore, NER regulation is of interest in fine-tuning these risks.
Distinct signaling cascades including the NFE2L2 (NRF2), AHR, PI3K/AKT1, MAPK, and CSNK2A1 pathways can modulate NER function.
In addition, several chemical and biological compounds have proven success in regulating NER’s activity.
These modulators, particularly the positive ones, could therefore provide potential treatments for genetic DNA repair-based diseases.
Negative modulators, nonetheless, can help sensitize cells to killing by genotoxic chemicals.
In this review, we will summarize and discuss the major upstream signaling pathways and molecules that could modulate the NER’s activity.
American Psychological Association (APA)
Kobaisi, F.& Fayyad, N.& Rezvani, Hamid Reza& Fayyad-Kazan, Mohammad& Sulpice, E.& Badran, Bassam…[et al.]. 2019. Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1203779
Modern Language Association (MLA)
Kobaisi, F.…[et al.]. Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1203779
American Medical Association (AMA)
Kobaisi, F.& Fayyad, N.& Rezvani, Hamid Reza& Fayyad-Kazan, Mohammad& Sulpice, E.& Badran, Bassam…[et al.]. Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1203779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203779