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Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKDLimkCofilin Signaling Pathway
Joint Authors
Xie, Min
Ju, Liping
Wu, Fei
Yu, Shuyan
Shang, Pan
Wang, Meijian
Jiang, Dongqing
Sun, Aili
Zhuang, Xianghua
Chen, Shihong
Xu, Min
Liu, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetic encephalopathy is a type of central diabetic neuropathy resulting from diabetes mainly manifested as cognitive impairments.
However, its underlying pathogenesis and effective treatment strategies remain unclear.
In the present study, we investigated the effect of Lipin1, a phosphatidic acid phosphatase enzyme, on the pathogenesis of diabetic encephalopathy.
We found that in vitro, Lipin1 exerts protective effects on high glucose-induced reductions of PC12 cell viability, while in vivo, Lipin1 is downregulated within the CA1 hippocampal region in a type I diabetes rat model.
Increased levels of Lipin1 within the CA1 region are accompanied with protective effects including amelioration of dendritic spine and synaptic deficiencies, phosphorylation of the synaptic plasticity-related proteins, LIM kinase 1 (p-limk1) and cofilin, as well as increases in the synthesis of diacylglycerol (DAG), and the expression of phosphorylated protein kinase D (p-PKD).
These effects are associated with the rescue of cognitive disorders as shown in this rat model of diabetes.
In contrast, knockdown of Lipin1 within the CA1 region enhanced neuronal abnormalities and the genesis of cognitive impairment in rats.
These results suggest that Lipin1 may exert neuroprotective effects involving the PKD/Limk/Cofilin signaling pathway and may serve as a potential therapeutic target for diabetic encephalopathy.
American Psychological Association (APA)
Xie, Min& Wang, Meijian& Liu, Wei& Xu, Min& Shang, Pan& Jiang, Dongqing…[et al.]. 2020. Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKDLimkCofilin Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203803
Modern Language Association (MLA)
Xie, Min…[et al.]. Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKDLimkCofilin Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1203803
American Medical Association (AMA)
Xie, Min& Wang, Meijian& Liu, Wei& Xu, Min& Shang, Pan& Jiang, Dongqing…[et al.]. Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKDLimkCofilin Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1203803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203803