Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism
Joint Authors
Liu, Bin
Song, Xianjin
Sun, Wei
Guan, Yinuo
Wang, Yiran
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular diseases have high morbidity and mortality rates worldwide, and their treatment and prevention are challenging.
MicroRNAs are a series of noncoding RNAs with highly conserved sequences and regulate gene expression by inhibiting mRNA transcription or degrading targeting proteins.
MicroRNA-210 is significantly upregulated during hypoxia and plays a protective role by inhibiting apoptosis and regulating cell proliferation, differentiation, migration, mitochondrial metabolism, and angiogenesis in hypoxic cells.
MicroRNA-210 expression is altered in cardiovascular diseases such as atherosclerosis, acute myocardial infarction, preeclampsia, aortic stenosis, and heart failure, and overexpression of microRNA-210 in some of these diseases exerts protective effects on target organs.
Furthermore, chronically upregulated miR-210 potentially plays a marked pathogenic role in specific situations.
This review primarily focuses on the upstream pathways, downstream targets, clinical progress in cardiovascular disease, and potential applications of microRNA-210.
American Psychological Association (APA)
Guan, Yinuo& Song, Xianjin& Sun, Wei& Wang, Yiran& Liu, Bin. 2019. Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203808
Modern Language Association (MLA)
Guan, Yinuo…[et al.]. Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1203808
American Medical Association (AMA)
Guan, Yinuo& Song, Xianjin& Sun, Wei& Wang, Yiran& Liu, Bin. Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1203808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203808